"The strikes hit an IS jail in Mayadeen at dawn on Monday, killing 42 prisoners and 15 jihadists," Observatory chief Rami Abdel Rahman told AFP.
Mayadeen lies in the Euphrates Valley some 45km southeast of the provincial capital of Deir Ezzor.
The Britain-based Observatory said that according to its sources IS had paraded the bodies of the dead in the streets of the town.
Most of Deir Ezzor province is controlled by the jihadists and it has been the target of air strikes by both the coalition and the Syrian army and its Russian ally.
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