One teen died at the scene, while the second died in hospital as a result of his injuries.
Two adults also suffered serious injuries in the incident, which happened shortly before midnight on Saturday.
Neighbours have told Mirror Online that there had been a party at the £600,000 home, and believe gatecrashers had turned up uninvited.
No arrests have been made, Thames Valley Police said in a statement this morning.
The scene is currently cordoned off as forensic officers gather evidence.
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